Latest Research
Exploring emerging treatments and scientific discoveries
In One Minute
Coeliac disease research is rapidly advancing. Current areas of investigation include alternative treatments beyond diet (enzyme therapies, vaccines, drugs to restore tolerance), improved diagnostic methods, understanding the role of the microbiome, and identifying environmental triggers. While the gluten-free diet remains the only proven treatment, future therapies may offer additional options for managing celiac disease.
Emerging Treatments Under Investigation
Enzyme Therapies
Phase 2/3 TrialsEnzymes designed to break down gluten proteins before they trigger an immune response. These may help protect against accidental gluten exposure but are not intended to replace the gluten-free diet.
Immune Modulators
Clinical TrialsMedications that target specific parts of the immune response to prevent intestinal damage when gluten is consumed. Several approaches are being tested including tight junction regulators.
Vaccine Approaches
Early PhaseVaccines designed to induce tolerance to gluten by retraining the immune system. Early trials show promise but more research is needed.
Advances in Diagnosis
Non-Invasive Testing
Research into blood tests that could diagnose celiac disease without requiring an endoscopy and biopsy. This includes improved antibody tests and genetic markers.
Point-of-Care Tests
Development of rapid diagnostic tests that could be performed in a doctor's office, similar to rapid strep tests, making screening more accessible.
Imaging Techniques
Advanced imaging methods like confocal laser endomicroscopy that could assess intestinal damage in real-time during endoscopy.
Understanding Disease Mechanisms
🔬 Microbiome Studies
Research shows that gut bacteria composition differs in people with celiac disease. Studies are exploring whether modifying the microbiome could prevent or treat the condition.
🧬 Genetic Research
While HLA-DQ2/DQ8 are necessary, they're not sufficient for celiac disease. Researchers are identifying additional genetic factors that influence disease development.
🦠Environmental Triggers
Studies investigating factors that trigger celiac disease in genetically susceptible people, including viral infections and early childhood feeding patterns.
🧪 Intestinal Barrier Function
Research on how gluten affects intestinal permeability and whether restoring barrier function could be therapeutic.
Clinical Trials
If you're interested in participating in celiac disease research, talk to your healthcare provider or visit ClinicalTrials.gov to find studies recruiting participants. Clinical trials are essential for developing new treatments.
Remember: The gluten-free diet remains the only proven, safe, and effective treatment for celiac disease. Any new therapies will complement, not replace, dietary management.
Research & Clinical Resources
Authoritative organisations providing evidence-based information and support for coeliac disease.
International Society for the Study of Celiac Disease research and publications.
InternationalLatest clinical trials and research developments in celiac disease.
United StatesUK-funded research projects and scientific advances.
United KingdomDatabase of current clinical trials for celiac disease treatments.
InternationalNote: External links are provided for informational purposes. We are not responsible for the content of external websites. Always consult healthcare professionals for medical advice.